Ever heard of the ‘kissing bug’ or Chagas disease? This is a tropical disease that is often neglected, but known to cause thousands of deaths.
Luckily, benznidazole has been approved by the US Food and Drug Administration to treat the tropical parasitic infection Chagas, or “kissing bug” disease, in children aged 2 to 12.
Faeces of blood-sucking bugs
Chagas disease (American trypanosomiasis) is caused by a parasite called Trypansosoma cruzi . According to the World Health Organization (WHO ) about six to seven million people worldwide are infected, specifically in Latin America, with an estimated 300 000 infected people in the United States according to the FDA.
This chronic debilitating condition is caused by the transmission of infected faeces of blood-sucking bugs. It can also be contracted through transfusion of infected blood, by organ transplantation or congenitally from an infected mother to her foetus.
Symptoms and diagnosis.
In most cases, symptoms are absent or mild, but can include fever, headache, enlarged lymph glands, muscle pain, difficulty breathing, swelling and abdominal or chest pain. In later years, the infection can lead to sudden death or heart failure, caused by progressive destruction of the heart muscle.
Diagnosis of infection in pregnant women, their newborns and siblings is especially important. While this disease is not a risk or an immediate threat in South Africa, people should still be aware of this disease when travelling to affected (tropical) areas, especially when pregnant or travelling with young children.
Serious heart problems
“The FDA is committed to making available safe and effective therapeutic options to treat tropical diseases,” said Dr Edward Cox, director of the Office of Antimicrobial Products in the FDA’s Center for Drug Evaluation and Research.
Chagas, also called American trypanosomiasis, may be spread through contact with insect faeces, during blood transfusion or from a mother to child during pregnancy, the FDA said in a news release. Left untreated, it can lead to serious heart problems, and affect swallowing and digestion.
In clinical testing, 55% to 60% of people treated with benznidazole had a negative antibody test for Chagas, the FDA said. The most common side effects of the medication included stomach pain, rash, weight loss, headache, nausea and vomiting. More serious risks could include skin reactions, nervous system problems and bone marrow issues.